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Article

Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2004

Inagaki-Ohara Kyoko, Chinen Takatoshi, Matsuzaki Goro, Sasaki Atsuo, Sakamoto Yukiko, Hiromatsu Kenji, Nakamura-Uchiyama Fukumi, Nawa Yukifumi, Yoshimura Akihiko

Abstract excerpt

Intestinal intraepithelial lymphocytes (IEL) bearing TCRgammadelta represent a major T cell population in the murine intestine. However, the role of gammadelta IEL in inflammatory bowel diseases (IBD) remains controversial. In this study, we show that gammadelta IEL is an important protective T cell population against IBD. gammadelta T cell-deficient (Cdelta(-/-)) mice developed spontaneous colitis with age and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15240735
DOI: 10.4049/jimmunol.173.2.1390

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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