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Article

Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice.

World journal of gastroenterology - 21 Jul 2014

Zhang Hanying, Xue Yansong, Wang Hui, Huang Yan, Du Min, Yang Qiyuan, Zhu Mei-Jun

Abstract excerpt

AIM: To test the role of mast cells in gut inflammation and colitis using interleukin (IL)-10-deficient mice as an experimental model. METHODS: Mast cell-deficient (Kit (W-sh/W-sh) ) mice were crossbred with IL-10-deficient mice to obtain double knockout (DKO) mice. The growth, mucosal damage and colitis status of DKO mice were compared with their IL-10-deficient littermates. RESULTS: DKO mice exhibited...

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Source

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Identifiers

PMID: 25083083
DOI: 10.3748/wjg.v20.i27.9106
PMCID: PMC4112873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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