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Article

Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.

Gastroenterology - 1 Apr 2005

Kai Yasuyuki, Takahashi Ichiro, Ishikawa Hiromichi, Hiroi Takachika, Mizushima Tsunekazu, Matsuda Chu, Kishi Daisuke, Hamada Hiromasa, Tamagawa Hiroshi, Ito Toshinori, Yoshizaki Kazuyuki, Kishimoto Tadamitsu, Matsuda Hikaru, Kiyono Hiroshi

Abstract excerpt

BACKGROUND & AIMS: Mice that have a truncated mutation of the common cytokine receptor gamma chain (CR gamma -/Y) are known to spontaneously develop colitis. To identify the pathologic elements responsible for triggering this localized inflammatory disease, we elucidated and characterized aberrant T cells and their enteropathogenic cytokines in CR gamma -/Y mice with colitis. METHODS: The histologic appearance,...

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Identifiers

PMID: 15825075
DOI: 10.1053/j.gastro.2005.01.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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