The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice.

doi:10.1016/s0016-5085(99)70128-9

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Article

The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice.

Gastroenterology - 1 Feb 1999

Mizoguchi A, Mizoguchi E, Bhan A K

Abstract excerpt

BACKGROUND & AIMS: T-cell receptor alpha mutant (TCRalpha-/-) mice spontaneously develop colitis resembling ulcerative colitis (UC). The role of interleukin (IL)-4 and interferon (IFN)-gamma in the pathogenesis of colitis was examined by creating IL-4- or IFN-gamma-deficient TCRalpha-/- mice. MET...

Topics

Animals
Colitis
Cytokines
Interferon-gamma
Interleukin-4
Lymph Nodes
Mesentery
Mice
Mutation
Receptors, Antigen, T-Cell, alpha-beta
Recombinant Proteins
Reverse Transcriptase Polymerase Chain Reaction

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