Article
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.
The Journal of clinical investigation - 1 Mar 2012
Li Xiangli, Murray Fiona, Koide Naoki, Goldstone Jonathan, Dann Sara M, Chen Jianzhong, Bertin Samuel, Fu Guo, Weinstein Lee S, Chen Min, Corr Maripat, Eckmann Lars, Insel Paul A, Raz Eyal
Abstract excerpt
cAMP, the intracellular signaling molecule produced in response to GPCR signaling, has long been recognized as an immunosuppressive agent that inhibits T cell receptor activation and T cell function. However, recent studies show that cAMP also promotes T cell-mediated immunity. Central to cAMP production downstream of GPCR activation is the trimeric G protein Gs. In order to reconcile the reports of divergent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.