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Article

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.

The Journal of clinical investigation - 1 Mar 2012

Li Xiangli, Murray Fiona, Koide Naoki, Goldstone Jonathan, Dann Sara M, Chen Jianzhong, Bertin Samuel, Fu Guo, Weinstein Lee S, Chen Min, Corr Maripat, Eckmann Lars, Insel Paul A, Raz Eyal

Abstract excerpt

cAMP, the intracellular signaling molecule produced in response to GPCR signaling, has long been recognized as an immunosuppressive agent that inhibits T cell receptor activation and T cell function. However, recent studies show that cAMP also promotes T cell-mediated immunity. Central to cAMP pr...

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Source

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Identifiers

PMID: 22326954
DOI: 10.1172/JCI59097
PMCID: PMC3287220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22326954-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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