Article
Noninvasive genotyping fetal Kell blood group (KEL1) using cell-free fetal DNA in maternal plasma by MALDI-TOF mass spectrometry.
Prenatal diagnosis - 1 Mar 2008
Li Ying, Finning Kirstin, Daniels Geoff, Hahn Sinuhe, Zhong Xiaoyan, Holzgreve Wolfgang
Abstract excerpt
BACKGROUND: Alloimmunization against the fetal Kell (KEL1) blood group antigen is gaining importance relative to the Rhesus problem and is the second most important cause of hemolytic disease of the fetus and newborn. Molecular diagnosis for fetal KEL1, which currently involves invasive procedures, is routinely done for accessing whether a fetus is at risk. Here we developed a matrix-assisted laser...
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