Noninvasive Antenatal Determination of Fetal Blood Group Using Next-Generation Sequencing.

doi:10.1101/cshperspect.a023093

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Article

Noninvasive Antenatal Determination of Fetal Blood Group Using Next-Generation Sequencing.

Cold Spring Harbor perspectives in medicine - 28 Oct 2015

Rieneck Klaus, Clausen Frederik Banch, Dziegiel Morten Hanefeld

Abstract excerpt

Hemolytic disease of the fetus and newborn (HDFN) is a condition characterized by a decreased lifespan of fetal red blood cells caused by maternally produced allospecific antibodies transferred to the fetus during pregnancy. The antibodies bind to the corresponding blood group antigens on fetal red blood cells and induce hemolysis. Cell-free DNA derived from the conceptus circulates in maternal blood. Using...

Topics

Blood Group Antigens
DNA
Female
Fetus
Genotype
High-Throughput Nucleotide Sequencing
Humans
Pregnancy
Prenatal Diagnosis
Sequence Analysis, DNA

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Identifiers

PMID: 26511760
DOI: 10.1101/cshperspect.a023093
PMCID: PMC4691807

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