Article
Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Ngo Vu N
Abstract excerpt
RNA interference (RNAi) is a conserved posttranscriptional gene silencing mechanism that has recently emerged as a breakthrough genetic tool in functional genomics and drug target discovery. An increasing number of studies applying RNAi in high-throughput screens have begun to unravel complex signaling networks underlying diverse cellular processes. This chapter describes an approach to construct a conditional...
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