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Article

Evidence that Xenon does not produce open channel blockade of the NMDA receptor.

Journal of neurophysiology - 1 Apr 2008

Weigt Henry U, Adolph Oliver, Georgieff Michael, Georgieff Eva M, Föhr Karl J

Abstract excerpt

Previous studies had not excluded the possibility that the mechanism by which Xenon (Xe) blocks N-methyl-D-aspartate (NMDA) receptors might be that of an open-channel blocker. We tested this possibility on mutant NMDA receptors carrying an alanine (A) to cysteine (C) mutation located within the SYTANLAAF-motif of the third transmembrane region (TM3). This mutation was shown to yield constitutively open ion...

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Source

Identifiers

PMID: 18234987
DOI: 10.1152/jn.00631.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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