Article
Activation of N-methyl-D-aspartate receptors by glycine: role of an aspartate residue in the M3-M4 loop of the NR1 subunit.
Molecular pharmacology - 1 Oct 1996
Williams K, Chao J, Kashiwagi K, Masuko T, Igarashi K
Abstract excerpt
Glutamate and glycine are coagonists that act at distinct sites to activate N-methyl-D-aspartate (NMDA) receptors. In the NR1 subunit of the NMDA receptor, mutation of D732 to glutamate (D732E), asparagine (D732N), alanine (D732A), or glycine (D732G) reduced the potency of glycine by > 4000-fold,...
Topics
- Amino Acid Sequence
- Aspartic Acid
- Binding Sites
- Extracellular Space
- Glutamic Acid
- Glycine
- Macromolecular Substances
- Magnesium
- Molecular Sequence Data
- Mutation
- Protein Folding
- Receptors, N-Methyl-D-Aspartate
- Sensitivity and Specificity