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Article

Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes.

The Journal of pharmacology and experimental therapeutics - 1 Jul 2006

Ogata Junichi, Shiraishi Munehiro, Namba Tsunehisa, Smothers C Thetford, Woodward John J, Harris R Adron

Abstract excerpt

Alcohols, inhaled anesthetics, and some injectable anesthetics inhibit the function of N-methyl-d-aspartate (NMDA) receptors, but the mechanisms responsible for this inhibition are not fully understood. Recently, it was shown that ethanol inhibition of NMDA receptors was reduced by mutation of residues in the transmembrane (TM) segment 3 of the NR1 subunit (F639A) or in TM4 of the NR2A subunit (A825W), suggesting...

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Source

Identifiers

PMID: 16622040
DOI: 10.1124/jpet.106.101691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes.PMID 16622040Read ↗

Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.Semantic proximity Read ↗

Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment.Semantic proximity Read ↗

Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants.Semantic proximity Read ↗

Differential effects of TM4 tryptophan mutations on inhibition of N-methyl-d-aspartate receptors by ethanol and toluene.Semantic proximity Read ↗

Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.Semantic proximity Read ↗

Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.Semantic proximity Read ↗

Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.Semantic proximity Read ↗

Sites of volatile anesthetic action on kainate (Glutamate receptor 6) receptors.Semantic proximity Read ↗

Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.Semantic proximity Read ↗

Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit.Semantic proximity Read ↗

Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes.Semantic proximity Read ↗

Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action.Semantic proximity Read ↗

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