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Article

Ethanol inhibition of constitutively open N-methyl-D-aspartate receptors.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2012

Xu Minfu, Smothers C Thetford, Trudell James, Woodward John J

Abstract excerpt

N-Methyl-D-aspartate (NMDA) receptors gate a slow and calcium-rich component of the postsynaptic glutamate response. Like all ionotropic glutamate receptors, NMDA subunits contain a highly conserved motif (SYTANLAAF) in the transmembrane (TM) 3 domain that is critically involved in channel gating. Mutation of an alanine in this domain (A7; underlined above) results in constitutively open receptors that show...

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Identifiers

PMID: 22005043
DOI: 10.1124/jpet.111.187179
PMCID: PMC3251024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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