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Article

Benzyl-polyamines: novel, potent N-methyl-D-aspartate receptor antagonists.

The Journal of pharmacology and experimental therapeutics - 1 Nov 1997

Igarashi K, Shirahata A, Pahk A J, Kashiwagi K, Williams K

Abstract excerpt

The effects of benzyl-polyamines were studied at recombinant N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus laevis oocytes. A number of mono-, di- and tri-benzyl polyamines, having benzyl substitutions on the terminal or central amino groups, inhibited responses of NR1/NR2 receptors in oocytes voltage-clamped at -70 mV. Among the most potent compounds was N1,N4, N8-tri-benzyl-spermidine (TB-3-4),...

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PMID: 9353367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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