Article
The shaker potassium channel is no target for xenon anesthesia in short-sleeping Drosophila melanogaster mutants.
TheScientificWorldJournal - 1 Jan 2012
Schaper C, Höcker J, Böhm R, Roeder T, Bein B
Abstract excerpt
BACKGROUND: Xenon seems to be an ideal anesthetic drug. To explore if next to the antagonism at the NMDA-receptor other molecular targets are involved, we tested the xenon requirement in short sleeping Drosophila shaker mutants and in na[har(38)]. METHODS: The Drosophila melanogaster strains wildtype Canton-S, na[har(38)], sh(102) and sh(mns), were raised and sleep was measured. Based on the response of the flies...
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