Article
Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding.
Anesthesiology - 1 Jul 2012
Armstrong Scott P, Banks Paul J, McKitrick Thomas J W, Geldart Catharine H, Edge Christopher J, Babla Rohan, Simillis Constantinos, Franks Nicholas P, Dickinson Robert
Abstract excerpt
BACKGROUND: Xenon is a general anesthetic with neuroprotective properties. Xenon inhibition at the glycine-binding site of the N-Methyl-D-aspartate (NMDA) receptor mediates xenon neuroprotection against ischemic injury in vitro. Here we identify specific amino acids important for xenon binding to the NMDA receptor, with the aim of finding silent mutations that eliminate xenon binding but leave normal receptor...
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