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Article

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

Nucleic acids research - 1 Mar 2008

Veprintsev Dmitry B, Fersht Alan R

Abstract excerpt

The tumour suppressor p53 is a transcription factor that binds DNA in the vicinity of the genes it controls. The affinity of p53 for specific binding sites relative to other DNA sequences is an inherent driving force for specificity, all other things being equal. We measured the binding affinities of systematically mutated consensus p53 DNA-binding sequences using automated fluorescence anisotropy titrations....

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Identifiers

PMID: 18234719
DOI: 10.1093/nar/gkm1040
PMCID: PMC2275157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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