Article

Conservation of affinity rather than sequence underlies a dynamic evolution of the motif-mediated p53/MDM2 interaction in teleosts

2023-08-24

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor and cell cycle regulator p53 is marked for degradation by the ubiquitin ligase MDM2. The interaction between these two proteins is mediated by a conserved binding motif in the disordered p53 transactivation domain (p53TAD) and the folded SWIB domain in MDM2. The conserved motif in p53TAD from zebrafish displays a 20-fold weaker interaction with MDM2, compared to the inte...

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Identifiers and source

Literature Corpus work: 77107c64-c961-5337-a2f3-1a1207c3fc37
DOI: 10.1101/2023.08.24.554616

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