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Article

Quantitative high-throughput analysis of transcription factor binding specificities.

Nucleic acids research - 27 Feb 2004

Linnell Jane, Mott Richard, Field Simon, Kwiatkowski Dominic P, Ragoussis Jiannis, Udalova Irina A

Abstract excerpt

We present a general high-throughput approach to accurately quantify DNA-protein interactions, which can facilitate the identification of functional genetic polymorphisms. The method tested here on two structurally distinct transcription factors (TFs), NF-kappaB and OCT-1, comprises three steps:...

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Identifiers

PMID: 14990752
DOI: 10.1093/nar/gnh042
PMCID: PMC390317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14990752-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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