Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Abstract excerpt

BACKGROUND: Transcription factors activate their target genes by binding to specific response elements. Many transcription factor families evolved from a common ancestor by gene duplication and subsequent divergent evolution. Members of the p53 family, which play key roles in cell-cycle control and development, share conserved DNA binding and oligomerisation domains but exhibit distinct functions. In this study,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biological Research and Disease Studies
• Share to Cancer-related Molecular Pathways
• Share to Epigenetics and DNA Methylation