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Navigating the complexity of p53-DNA binding: implications for cancer therapy

11 Jul 2024

Abstract excerpt

Abstract: The tumor suppressor protein p53, a transcription factor playing a key role in cancer prevention, interacts with DNA as its primary means of determining cell fate in the event of DNA damage. When it becomes mutated, it opens damaged cells to the possibility of reproducing unchecked, which can lead to formation of cancerous tumors. Despite its critical role, therapies at the molecular level to restore...

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PMID: 39309126
DOI: 10.1007/s12551-024-01207-4

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