Article
The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
Blood - 1 Apr 2008
de Gorter David J J, Reijmers Rogier M, Beuling Esther A, Naber Hildegonda P H, Kuil Annemieke, Kersten Marie José, Pals Steven T, Spaargaren Marcel
Abstract excerpt
Chemokine-controlled migration plays a critical role in B-cell development, differentiation, and function, as well as in the pathogenesis of B-cell malignancies, including the plasma cell neoplasm multiple myeloma (MM). Here, we demonstrate that stimulation of B cells and MM cells with the chemokine stromal cell-derived factor-1 (SDF-1) induces strong migration and activation of the Ras-like GTPase Ral....
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