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LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma

3 Jan 2025

Abstract excerpt

Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and was associated with poor prognosis in patients with MM. However, the mechanism of cell homing and migration, which is critical for MM progression, remains unclear. In the present study, cell...

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PMID: 39749708
DOI: 10.3892/ijo.2025.5718

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