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RalA and RalB: Antagonistic Relatives in Cancer Cell Migration

15 Aug 2005

Abstract excerpt

The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions of RalA and RalB in regulating cell migration, a necessary component of the invasive phenotype, in...

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PMID: 16103060
DOI: 10.1158/0008-5472.can-04-1957

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