Article

Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes

2020-07-10

Abstract excerpt

Cancer extracellular vesicles (EVs) mainly exert pro-tumoral functions by changing the phenotypes of stromal cells to the benefit of tumor growth and metastasis. They shuttle to distant organs and fertilize pre-metastatic niches facilitating subsequent seeding by circulating tumor cells. The levels of tumor secreted EVs correlate with tumor aggressiveness, however, the link between EV secretion mechanisms and thei...

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Literature Corpus work: 4b99e88b-b107-5699-bae6-fb90714791e3
DOI: 10.1101/2020.07.10.196691

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