Article
The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target.
Urologic oncology - 1 Jan 2000
Smith Steven Christopher, Theodorescu Dan
Abstract excerpt
Bladder cancer is a relatively common and strikingly costly malignancy. Here, we will focus on recent advances in our understanding of the molecular pathogenesis of metastatic bladder cancer, a stage of this disease curable in only a minority of patients. Our group has recently investigated the role of a class of small G-proteins known as the Ras-like or Ral GTPases and their role in this disease. These signaling...
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