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Article

Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy?

Cellular signalling - 1 Jun 2011

Lazer Galit, Katzav Shulamit

Abstract excerpt

Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as molecular switches in a variety of signaling pathways following stimulation of cell surface receptors. RhoGTPases regulate numerous cellular processes including cytoskeleton organization, gene transcription, cell proliferation, migration, growth and cell survival. Because of their central role in regulating processes that are...

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PMID: 21044680
DOI: 10.1016/j.cellsig.2010.10.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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