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Article

Phosphorylation of RalB is important for bladder cancer cell growth and metastasis.

Cancer research - 1 Nov 2010

Wang Hong, Owens Charles, Chandra Nidhi, Conaway Mark R, Brautigan David L, Theodorescu Dan

Abstract excerpt

RalA and RalB are monomeric G proteins that are 83% identical in amino acid sequence but have paralogue-specific effects on cell proliferation, metastasis, and apoptosis. Using in vitro kinase assays and phosphosite-specific antibodies, here we show phosphorylation of RalB by protein kinase C (PKC) and RalA by protein kinase A. We used mass spectrometry and site-directed mutagenesis to identify S198 as the...

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Identifiers

PMID: 20940393
DOI: 10.1158/0008-5472.CAN-10-0952
PMCID: PMC3025490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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