Article
Mitochondrial D310 mutations in colorectal adenomas: an early but not causative genetic event during colorectal carcinogenesis.
International journal of cancer - 15 May 2008
Legras Antoine, Lièvre Astrid, Bonaiti-Pellié Catherine, Cottet Vanessa, Pariente Alexandre, Nalet Bernard, Lafon Jacques, Faivre Jean, Bonithon-Kopp Claire, Goasguen Nicolas, Penna Christophe, Olschwang Sylviane, Laurent-Puig Pierre
Abstract excerpt
Somatic mutations of the D310 sequence of the mitochondrial DNA are reported in human cancers, including colorectal cancers (CRC). The presence of these mutations at early or late steps of colorectal carcinogenesis is unknown. Their prevalence increased significantly with the number of cytosines in the D310 sequence of the matched normal tissue (D310 polymorphism), suggesting that this polymorphism could be a...
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