Article
The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas.
The Journal of endocrinology - 1 Nov 1998
Yoshimoto T, Naruse M, Zeng Z, Nishikawa T, Kasajima T, Toma H, Yamamori S, Matsumoto H, Tanabe A, Naruse K, Demura H
Abstract excerpt
To explore the clinical significance of p53 in the pathogenesis of adrenal neoplasms, we investigated the incidence of p53 gene mutations in functioning human adrenal tumours using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique to screen p53 exons 4 to 9. We examined 29 adrenocortical adenomas (primary aldosteronism, n=17; Cushing's syndrome, n=12, all benign), and 33...
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