Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.

doi:10.1111/j.1474-9726.2008.00371.x

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Article

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.

Aging cell - 1 Mar 2008

Morcos Michael, Du Xueliang, Pfisterer Friederike, Hutter Harald, Sayed Ahmed A R, Thornalley Paul, Ahmed Naila, Baynes John, Thorpe Suzanne, Kukudov Georgi, Schlotterer Andreas, Bozorgmehr Farastuk, El Baki Randa Abd, Stern David, Moehrlen Frank, Ibrahim Youssef, Oikonomou Dimitrios, Hamann Andreas, Becker Christian, Zeier Martin, Schwenger Vedat, Miftari Nexhat, Humpert Per, Hammes Hans-Peter, Buechler Markus, Bierhaus Angelika, Brownlee Michael, Nawroth Peter P

Abstract excerpt

Studies of mutations affecting lifespan in Caenorhabditis elegans show that mitochondrial generation of reactive oxygen species (ROS) plays a major causative role in organismal aging. Here, we describe a novel mechanism for regulating mitochondrial ROS production and lifespan in C. elegans: progressive mitochondrial protein modification by the glycolysis-derived dicarbonyl metabolite methylglyoxal (MG). We...

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PMID: 18221415
DOI: 10.1111/j.1474-9726.2008.00371.x

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