Article
Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.
Molecular genetics and metabolism - 1 Apr 2008
Falk M J, Zhang Z, Rosenjack J R, Nissim I, Daikhin E, Nissim I, Sedensky M M, Yudkoff M, Morgan P G
Abstract excerpt
Caenorhabditis elegans affords a model of primary mitochondrial dysfunction that provides insight into cellular adaptations which accompany mutations in nuclear genes that encode mitochondrial proteins. To this end, we characterized genome-wide expression profiles of C. elegans strains with mutations in nuclear-encoded subunits of respiratory chain complexes. Our goal was to detect concordant changes among...
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