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Article

The role of O-linked GlcNAc modification on the glucose response of ChREBP.

Biochemical and biophysical research communications - 26 Nov 2010

Sakiyama Haruhiko, Fujiwara Noriko, Noguchi Takahiro, Eguchi Hironobu, Yoshihara Daisaku, Uyeda Kosaku, Suzuki Keiichiro

Abstract excerpt

The carbohydrate response element-binding protein (ChREBP) functions as a transcription factor in mediating the glucose-activated gene expression of multiple liver enzymes, which are responsible for converting excess carbohydrate to storage fat. ChREBP is translocated into the nucleus in response to high glucose levels, and then up-regulates transcriptional activity. Although this glucose activation of ChREBP is...

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Source

Identifiers

PMID: 21036147
DOI: 10.1016/j.bbrc.2010.10.113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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