Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.

The Journal of biological chemistry - 29 Aug 2008

Davies Michael N, O'Callaghan Brennon L, Towle Howard C

Abstract excerpt

Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that activates genes involved in de novo lipogenesis in mammals. The current model for glucose activation of ChREBP proposes that increased glucose metabolism triggers a cytoplasmic to nuclear translocation of ChREBP that is critical for activation. However, we find that ChREBP actively shuttles between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucose
Share to Active Transport, Cell Nucleus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Share to Cell Nucleus

Share to Cytoplasm

Share to Lipids

Share to Repressor Proteins

Share to Sweetening Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 18591247
DOI: 10.1074/jbc.M801539200
PMCID: PMC2527113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.PMID 18591247Read ↗

Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.Semantic proximity Read ↗

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.Semantic proximity Read ↗

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β CellsSemantic proximity Read ↗

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene ExpressionSemantic proximity Read ↗

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.Semantic proximity Read ↗

MondoA/ChREBP: The usual suspects of transcriptional glucose sensing; Implication in pathophysiologySemantic proximity Read ↗

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.Semantic proximity Read ↗

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loopSemantic proximity Read ↗

Hexokinase domain-containing protein-1 in metabolic diseases and beyondSemantic proximity Read ↗

The role of O-linked GlcNAc modification on the glucose response of ChREBP.Semantic proximity Read ↗

The polyol pathway is an evolutionarily conserved system for sensing glucose uptakeSemantic proximity Read ↗

Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.