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Article

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.

Nature - 19 Apr 2012

Herman Mark A, Peroni Odile D, Villoria Jorge, Schön Michael R, Abumrad Nada A, Blüher Matthias, Klein Samuel, Kahn Barbara B

Abstract excerpt

The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor. Insulin stimulates glucose uptake in adipose tissue through the GLUT4 (also known as SLC2A4) glucose transporter, and alterations in adipose tissue GLUT4 expression or function regulate systemic insulin sensitivity. Downregulation of...

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Share to Adipocytes
Share to Adipose Tissue
Share to Adiposity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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Source

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Identifiers

PMID: 22466288
DOI: 10.1038/nature10986
PMCID: PMC3341994

Genes

MLXIPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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