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Article

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease.

Immunology - 1 Jan 2016

Prochazkova Jana, Loizou Joanna I

Abstract excerpt

In recent years, several novel congenital human disorders have been described with defects in lymphoid B-cell and T-cell functions that arise due to mutations in known and/or novel components of DNA repair and damage response pathways. Examples include impaired DNA double-strand break repair, as well as compromised DNA damage-induced signal transduction, including phosphorylation and ubiquitination. These...

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Identifiers

PMID: 26455503
DOI: 10.1111/imm.12547
PMCID: PMC4988471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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