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Article

Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease.

The American journal of gastroenterology - 1 Jul 2009

Török Helga P, Glas Jürgen, Endres Ilona, Tonenchi Laurian, Teshome Molla Y, Wetzke Martin, Klein Wolfram, Lohse Peter, Ochsenkühn Thomas, Folwaczny Matthias, Göke Burkhard, Folwaczny Christian, Müller-Myhsok Bertram, Brand Stephan

Abstract excerpt

OBJECTIVES: Recent data suggest functional interactions between NOD2 and other receptors of the innate immune system modulating inflammatory responses. Here we analyzed the role of Toll-like receptor 9 (TLR-9) gene variants with respect to susceptibility to inflammatory bowel disease (IBD) and tested for genetic interactions with NOD2 and other susceptibility genes for Crohn's disease (CD). METHODS: The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19455129
DOI: 10.1038/ajg.2009.184

Genes

NOD2
TLR9
DLG5

Variants

rs5743836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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