Article
Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association.
The American journal of gastroenterology - 1 Nov 2007
Browning Brian L, Huebner Claudia, Petermann Ivonne, Gearry Richard B, Barclay Murray L, Shelling Andrew N, Ferguson Lynnette R
Abstract excerpt
OBJECTIVES: Published association studies of the TLR4 Asp299Gly polymorphism and inflammatory bowel disease (IBD) in caucasian populations have inconsistent results. We tested two TLR4 variants for association with IBD in the New Zealand caucasian population and assessed the cumulative evidence for association of TLR4 Asp299Gly and IBD. METHODS: The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and...
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