Article
TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.
Journal of gastroenterology and hepatology - 1 Nov 2007
Hong Jiwon, Leung Euphemia, Fraser Alan G, Merriman Tony R, Vishnu Prakash, Krissansen Geoffrey W
Abstract excerpt
BACKGROUND AND AIM: Toll-like receptors (TLRs) have been identified as susceptibility genes for Crohn's disease (CD) in some, but not all, studies. Here we examined the association between candidate disease-susceptibility polymorphisms in the TLR2, TLR4 and TLR9 genes and CD in a New Zealand Caucasian population. METHODS: The frequency of gene polymorphisms was examined in 182 CD patients and in 188 ethnically...
Topics
- Amplified Fragment Length Polymorphism Analysis
- Case-Control Studies
- Cohort Studies
- Crohn Disease
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- New Zealand
- Odds Ratio
- Phenotype
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic