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Article

Epistatic interaction between TLR4 and NOD2 in patients with Crohn's Disease: relation with risk and phenotype in a Spanish cohort.

Immunobiology - 1 Sept 2016

Martinez-Chamorro Alba, Moreno Antonia, Gómez-García María, Cabello María José, Martin Javier, Lopez-Nevot Miguel Ángel

Abstract excerpt

Crohn's Disease is one of the two major forms of the Inflammatory Bowel Diseases and, although the etiology is not completely understood, the confluence of environmental and genetic factors has been demonstrated. The aim of this study was to determine the distribution of TLR4 variants in a Spanish cohort of Crohn's Disease patients and their relation with phenotype and common NOD2 variants. A total of 371 Crohn's...

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Identifiers

PMID: 27290609
DOI: 10.1016/j.imbio.2016.05.015

Genes

NOD2
TLR4

Variants

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