Article

A Novel Rare Missense Variation of the <em>NOD2</em> Gene: Evidences of Implication in Crohn’s Disease

2018-11-20

Abstract excerpt

The NOD2 gene, involved in innate immune responses to bacterial peptidoglycan, has been found to be strongly associated with Crohn’s Disease, with an Odd Ratio ranging from 3 to 36. Families with 3 or more CD affected patients were related to high frequency of NOD2 gene variations as R702W, G908R, 1007fs and were reported in EPIMAD Registry. However, some rare CD multiplex families were described without ide...

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Literature Corpus work: af57f9a0-7b45-5c40-8a24-bf4c38efa9de
DOI: 10.20944/preprints201811.0488.v1

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