Article
Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.
Human mutation - 1 Apr 2008
Paisán-Ruíz Coro, Nath Priti, Washecka Nicole, Gibbs J Raphael, Singleton Andrew B
Abstract excerpt
Mutation of LRRK2, encoding dardarin, is the most common known genetic cause of Parkinson's disease (PD). The large size of this gene and the relative ease with which the most common mutations can be screened means that although more than 50 LRRK2 screening papers have been published, few have analyzed the entire coding sequence. Furthermore, no comprehensive sequence-based analysis has been performed on control...
Topics
- Base Sequence
- Case-Control Studies
- DNA
- Exons
- Gene Deletion
- Gene Dosage
- Gene Duplication
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Mutation, Missense
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Protein Serine-Threonine Kinases