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Updated MDSGene review on the clinical and genetic spectrum of LRRK2 variants in Parkinson´s disease

17 Feb 2025

Abstract excerpt

Pathogenic variants in the LRRK2 gene are one of the most commonly identifiable monogenic causes of Parkinson´s disease (PD, PARK-LRRK2). This systematic MDSGene literature review comprehensively summarizes published demographic, clinical, and genetic findings related to LRRK2 variants ( https://www.mdsgene.org/ ). Data on 4660 individuals with 283 different variants were curated. The median age at onset in the...

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PMID: 39962078
DOI: 10.1038/s41531-025-00881-9

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