Article
LRRK2 mutations in a clinic-based cohort of Parkinson's disease.
European journal of neurology - 1 Dec 2006
Scholz S, Mandel R J, Fernandez H H, Foote K D, Rodriguez R L, Barton E, Munson S, Singleton A, Okun M S
Abstract excerpt
In the last decade, major breakthroughs in the understanding of genetic contributions to Parkinson's disease (PD) have been achieved. Recently, mutations in LRRK2, encoding dardarin, have been found to be responsible for an autosomal dominant parkinsonism (OMIM 607060). We screened 311 subjects (cases: n = 202, controls: n = 109) for the three previously reported LRRK2 mutations. Our investigation revealed a...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- Child
- Cohort Studies
- Female
- Gene Amplification
- Genotype
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2