Article
LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Neurology - 30 Oct 2007
Nichols W C, Elsaesser V E, Pankratz N, Pauciulo M W, Marek D K, Halter C A, Rudolph A, Shults C W, Foroud T
Abstract excerpt
BACKGROUND: Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been found to cause typical, later-onset Parkinson disease (PD). Although G2019S is the most common mutation, other mutations have also been reported. It is critical to catalog the types of mutations found in L...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- Exons
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lod Score
- Male
- Microsatellite Repeats
- Middle Aged
- Parkinson Disease