Article
Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Neuro-degenerative diseases - 1 Jan 2007
Johnson Janel, Paisán-Ruíz Coro, Lopez Grisel, Crews Cynthia, Britton Angela, Malkani Roniel, Evans E Whitney, McInerney-Leo Aideen, Jain Shushant, Nussbaum Robert L, Foote Kelly D, Mandel Ronald J, Crawley Anthony, Reimsnider Sharon, Fernandez Hubert H, Okun Michael S, Gwinn-Hardy Katrina, Singleton Andrew B
Abstract excerpt
BACKGROUND: Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosomal dominant form of parkinsonism. OBJECTIVE: To identify mutations causing Parkinson's disease (PD) in a cohort of North Americans with familial PD. METHODS: We sequenced exons 1-51 of LRRK2 in 79...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alternative Splicing
- Amino Acid Sequence
- Amino Acid Substitution
- Base Sequence
- Brain Chemistry
- Cohort Studies