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Article

Detection of single-nucleotide polymorphisms using gold nanoparticles and single-strand-specific nucleases.

Analytical biochemistry - 15 Apr 2008

Chen Yen-Ting, Hsu Chiao-Ling, Hou Shao-Yi

Abstract excerpt

The current study reports an assay approach that can detect single-nucleotide polymorphisms (SNPs) and identify the position of the point mutation through a single-strand-specific nuclease reaction and a gold nanoparticle assembly. The assay can be implemented via three steps: a single-strand-specific nuclease reaction that allows the enzyme to truncate the mutant DNA; a purification step that uses capture...

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PMID: 18211817
DOI: 10.1016/j.ab.2007.12.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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