Article
Electrochemical coding of single-nucleotide polymorphisms by monobase-modified gold nanoparticles.
Analytical chemistry - 1 Apr 2004
Kerman Kagan, Saito Masato, Morita Yasutaka, Takamura Yuzuru, Ozsoz Mehmet, Tamiya Eiichi
Abstract excerpt
Rapidly increasing information about the human genome requires a fast and simple method for the detection of single-nucleotide polymorphisms (SNPs). To date, the conventional SNP detection technologies have been unable to identify all possible SNPs and needed further development in cost, speed, and sensitivity. Here we describe a novel method to discriminate and code all possible combinations. SNPs were coded by...
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