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Article

Non-cross-linking gold nanoparticle aggregation as a detection method for single-base substitutions.

Nucleic acids research - 7 Jan 2005

Sato Kae, Hosokawa Kazuo, Maeda Mizuo

Abstract excerpt

Aggregation of DNA-modified gold nanoparticles in a non-cross-linking configuration has extraordinary selectivity against terminal mismatch of the surface-bound duplex. In this paper, we demonstrate the utility of this selectivity for detection of single-base substitutions. The samples were prepared through standard protocols: DNA extraction, PCR amplification and single-base primer extension....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15640441
DOI: 10.1093/nar/gni007
PMCID: PMC546178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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