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Article

Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro.

Journal of gastroenterology and hepatology - 1 Jul 2008

Whitehead Robert H, Robinson Pamela S, Williams Janice A, Bie Wenjun, Tyner Angela L, Franklin Jeffrey L

Abstract excerpt

BACKGROUND AND AIMS: PTK6 is an intracellular src-related tyrosine kinase that regulates differentiation in the intestine, where knockout animals have increased proliferative activity and growth characteristics. To explore the phenotype further we attempted to establish epithelial cell lines from the intestinal mucosa. METHOD: We mated Ptk6 null mice with a tsSV40 large T transgenic mouse (Immortomouse) to obtain...

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Identifiers

PMID: 18205771
DOI: 10.1111/j.1440-1746.2008.05308.x
PMCID: PMC3005200

Genes

PTK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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