Article

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis

2021-02-22

Abstract excerpt

<title>Abstract</title> <p>Intestinal epithelial self-renewal is tightly regulated by signaling pathways controlling stem cell proliferation, determination and differentiation. In particular, Wnt/β-catenin signaling controls crypt cell division and survival and is required for maintenance of the intestinal stem cell niche. Most colorectal cancers are also initiated by mutations activating the Wnt/β-catenin pathwa...

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Literature Corpus work: 99cbbcd0-7d3b-50a3-b0d7-cc1bd5ee4888
DOI: 10.21203/rs.3.rs-199544/v1

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